One important key to a game like this is head coach and play caller Hue Jackson, and the offensive game plan he puts together. In past weeks, and especially last week against the New England Patriots, the run to pass ratio has been lopsided, making for a very unbalanced offense.
Going up against a defense like the Titans there is no reason to heavily favor the running game or the passing game. Tennessee gives up the ninth-fewest passing yards, and the 14th-fewest rushing yards. This makes them an overall solid defense. But the biggest takeaway from this stat is that balanced offense will work best, running the ball early to set up play-action passing options later in the game.
It actually is somewhat surprising that the Titans are ranked as well as they are on defense, since they have no real superstar defender. But what they do have is solid linebacker play from Brian Orakpo and Derrick Morgan especially. This underscores the need to mix up the play calling, as the linebackers defend both the pass and the run. Making the plays unpredictable is an important step to throwing the defense off-balance. If the Browns can do this, they can at least put themselves in positions which gives them opportunities to make plays on offense and score a substantial amount of points.