Dawg Pound Daily’s picks against the spread for Week 1 of the 2010 NFL season:
| Week 1 | Steve | Jimmy |
| Dolphins (-3) @ Bills | Dolphins | Bills |
| Raiders @ Titans (-6.5) | Titans | Titans |
| Broncos @ Jaguars (-3) | Broncos | Jaguars |
| Panthers @ Giants (-7) | Giants | Panthers |
| Colts (-2.5) @ Texans | Texans | Texans |
| Falcons (-1.5) @ Steelers | Falcons | Falcons |
| Browns @ Bucs (-3) | Browns | Browns |
| Bengals @ Patriots (-5.5) | Bengals | Bengals |
| Lions @ Bears (-6.5) | Bears | No pick |
| Packers (-3) @ Eagles | Packers | Eagles |
| 49ers (-3) @ Seahawks | 49ers | Seahawks |
| Cardinals (-4) @ Rams | Cardinals | Rams |
| Cowboys (-3.5) @ Redskins | Cowboys | Redskins |
| Ravens @ Jets (-2) | Ravens | Jets |
| Chargers (-5) @ Chiefs | Chargers | Chargers |